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summer cologne to help you keep your cool

Burberry Summer: This limited edition fragrance has the freshness of yuzu leaves and mandarin and mixes them with mint, juniper berries and thyme. It's tranquil, masculine, sensual, woody and like Tsang says, it fits the aromatic bill of the ultimate bachelor. less

Burberry Summer: This limited edition fragrance has the freshness of yuzu leaves and mandarin and mixes them with mint, juniper berries and thyme. It's tranquil, masculine, sensual, woody and like Tsang says, . more

Kilian Prelude to Love, Invitation Eau de Parfum: Encased in a swanky box, Prelude to Love, Invitation is a refined combo of sweet Calabria bergamot, delicate Seville orange and bright Italian lemon " with the love coming bulgari ring copy from Florence iris. Its like a European summer bouquet for your nostrils (Saks Fifth Avenue; 1.7 oz, $225). less

Kilian Prelude to Love, Invitation Eau de Parfum: Encased in a swanky box, Prelude to ring bvlgari imitation Love, Invitation is a refined combo of sweet Calabria bergamot, delicate Seville orange and bright Italian lemon " replica gold bvlgari ring . more

When it comes to fragrances, many men tend to keep one bottle of cologne in their medicine cabinet until it wheezes nothing but scented air through its worn out nozzle. But just as one's wardrobe changes with imitation bvlgari b zero1 diamond ring the seasons, it's ideal to change your colognes particularly for summer.

"The hotter our bodies are, the more a fragrance is amplified, which is why most gravitate to softer, sweeter fragrances in the spring summer, and warmer, gourmand note fragrances during the fall and winter," says , a fragrance expert from Sephora on Powell Street.

"We tend to brave the heat with a light scent to keep ourselves feeling refreshed, yet sweet smelling."

There are three major fragrance categories for men: fresh, aromatic and woody, each representing a different personality and seasonal appeal, Tsang says.

"Fresh scents are clean and refreshing and blend citrus notes. Aromatic scents are for the masculine and independent men who enjoy the classic mix of notes of citrus, lavender, orange, ginger, black currant, lime and sweet spices, (while) woody scents are blends of cedar, vetiver and sandalwood."

There's a strategy to choosing a summer friendly cologne that suits your needs and that is a step up from Axe Body sprays.

Fragrance specialist at Union Square says that it should take only 10 minutes to determine whether a fragrance is right for you.

"Avoid buying a fragrance without testing it on your skin," she advises. "Your body oil or body chemistry will determine it in 10 minutes."

Where to apply fragrance to maximize its power without torturing the olfactory senses of those around you? Murray says the best way to apply a fragrance is on your pulse points: inside your wrists, elbows, knees; behind the ears; and behind the neck. She also suggests where not to apply it.

"Never apply it on your chest, because when your body warms up, the heat rises, and it's the first thing that loudly greets the person who is in front of you," she says.

This limited edition fragrance has the freshness of yuzu leaves and mandarin mixed with mint, juniper berries and thyme. It's tranquil, masculine, sensual, woody and fits the aromatic bill of the ultimate bachelor, Kevan Tang says. It's a summer scent suitable for the beach which shows in the hard bodied torso bottle. It's like a European summer bouquet for your nostrils. ($225, 1.7 ounces eau de parfum, Saks Fifth Avenue.).
PKKOO5 one hour ago
Ashley Graham reveals she's a fan or America's Next Top Model and Tyra Banks

Ashley Graham was a vision at the MTV Video Music Awards on Sunday Night, hitting the carpet in a sheer, custom made dress by Naeem Khan while talking about her first season as a judge on America's Next Top Model.

Talk then turned to past contestants on the show, and Graham had no problem quickly rattling off a few of her favorite, naming Yaya Decosta andToccara Jones as two of the beauties who stuck out to her.

DaCosta was the runner up on the show's third season and went on to find success in both the modeling and film worlds, recently appearing in the Ryan Gosling film The Nice Guy and last year as Whitney Houston in the late singer's Lifetime biopic.

Jones appeared on the third cycle as well, but the plus sized stunner exited the program early on, finishing seventh among the girls.

She found success in the years after however and in 2008 landed the cover of Italian Vogue along with a 14 page spread in the fashion magazine.

With her first season as a judge wrapped, Graham is also now busy getting to work on her lingerie collection for Addition Elle, which she will show on September 14 during New York Fashion Week in a show presented by Style 360.

'I'm very excited about,' said Graham, who in addition to attending the show on Sunday night also made a cameo during Nick Jonas' performance of Bacon.

It was not the model's first time appearing alongside a Jonas replica bvlgari b zero1 diamond ring brother either, with the Graham appearing in the music video for Toothbrush earlier this year, the Bulgari wedding ring replica second single of the debut album of Nick's older brother Joe and his band DNCE.

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    Crafting a successful business

    TORONTO Not too many people are willing to risk a steady paycheque to pursue a passion. Fewer still can channel that passion and build it into a successful business.

    For jeweller Linda Penwarden, the path to success as an independent business owner has been a gradual and steady one.

    In the jewelry business for nearly two decades, Penwarden has worked hard to carve out a healthy niche for herself over the past nine years at her store, , in midtown Toronto. It's a neighbourhood that has grown steadily and prospered over the past decade since she set up shop there.

    In that time, Penwarden has learned a few things about necessities that come with being your own boss. First and foremost: Do the homework.

    "Definitely take a business course (before you launch your business). Really learn your business. Learn everything about the business that you can possibly learn," says Penwarden.

    It sounds like simple advice, but it's not uncommon for businesses to fail on poor planning a lack of preparedness for, or understanding of, one crucial aspect of the business or another.

    There's a fake bulgari necklace balancing act involved with doing what you love and running it as a business. The former is frequently romanticized among the nine to five set, while the nuts and bolts of the business side tends to be forgotten Penwarden's own shop is a perfect illustration.

    On the ground level is the store an elegant, sparsely decorated studio with simple glass cases showcasing her work.

    The upper level has all the grit and functionality of a real workshop. Well worn workbenches are littered with tools and supplies, while her employees pound, pour and ply the new pieces together.

    Penwarden's office, also on the second floor, is piled high with sketches of her latest designs.

    Ignoring the business side is a luxury Penwarden can't afford. But running a business was hardly second nature.

    "There were lots of challenges, in the beginning, because I just had an art background," says Penwarden, who studied at the Ontario College of Arts and Design, and also was a student of goldsmithing at George Brown College. "I didn't have a management or business background. So everything was just a huge learning curve for me, from accounting to managing people to keeping track of inventory, computers . . . Still to this day there are a lot of challenges on a daily basis."

    The solution for Penwarden was to start small and build slowly, one step at a time. She spent several years working for other, more established jewellers paying her dues, honing her skills and building up a base to eventually strike out on her own. She started with an online only business on the side before she finally felt she was ready to open her own store.

    "I've always wanted to have my own place or my own business," she says. "I never really wanted to work for another company for a long period of time or anything like that. And it just kept building up. My clientele just kept building, building, building to the point where I didn't have to work anywhere else."

    In the early years, Penwarden faced a list of limitations, many of which are common to small, independent start up ventures. There are the typical costs, in time and money, of getting the shop ready. And it took a while to build up an inventory of jewelry to display in the cases at first she couldn't even afford the more expensive gemstones that are now prominently displayed in her cases.

    "It's not like I've got (Italian jeweler) Bulgari's vault, that I can work their gems, you know. It's improving, but in the beginning a big limitation was just the money," she says.

    "I had limited funds, so you had to design what you could design with."

    Most of the imitation bvlgari necklace time, she was the only person in the store although bulgari necklace fake she had occasional help from a friend. And while she had built relationships through her previous jobs and her online business, it took some time to earn herself a local _and loyal clientele.

    "Someone from the neighbourhood (would come into the store)," she says. "You know, they're just testing the waters because jewelry's a big purchase, so they don't know if I'm going to be closing the doors in a year or six months from now. So they'll start out and buy their wife something small. And then the next year it'll be something a little better and then the year after that."

    While she's established herself at her present location, it remains a challenge to continue to grow and nurture the business, whether it's the day to day needs of managing staff and securing inventory or building word of mouth and advertising.

    Still, she insists that these challenges don't take away from her passion for her craft.

    "The whole reason to owning my own business," she says, "was to do what I want to do and have a bit of freedom knock off bvlgari necklace take a vacation when I want to take a vacation, that sort of thing. And create what I want to create, not having these boundaries of another designer. That's my favourite part of the job is making things, designing things, and also making people happy."

    Being independent also allows her to remain true to a set of principles that she might have had to compromise as someone else's employee. For one, she prides herself in the fact that all of her creations are designed and produced in house, rather than being outsourced to a factory overseas a cost cutting measure that has become increasingly common practice in her industry. She also, where possible, strives to purchase materials from ethical sources.

    "I would always maintain Canadian product," she says. "I'm very passionate about that. I'm very passionate about keeping Canadians employed, keeping things local. I would never open up factories overseas. Never. . . . I'm really passionate about that. I feel it's like shooting yourself in the foot or eating your own young."

    Running a small business and keeping the work in house allows for greater control over quality something that she fears might be compromised if she were to over extend her business.

    "I've seen it with some brands where they have lost a little bit of quality by going too big, too soon," she says. "And it's almost cheapening the brand because it's too many outlets now. Also I think if you have a good team who follows your integrity, who follows your quality control, I think you can grow the business and still maintain the quality.

    "You have to make sure everybody's on point. Everybody knows what my vision is. I would like to grow the business, of course. But it's a matter of getting those right people in place to help. You can't do it all. I could design all day, but you know, to market and to do all that, it takes another type of person."

    Ultimately, it all comes back to the ability to create things that people love things that people connect with emotionally that Penwarden finds most rewarding about the work she does.

    "I love the reaction, the emotion that comes along with what we provide. To see someone so touched when they see the piece of jewelry and the excitement. It's just making people happy the final product.
    PKKOO5 3 hours ago
    Joran Van Der Sloot Extradition Process Started For Extortion From Natalee Holloway

    The process to extradite Joran van der Sloot from Peru to the United States has begun, CNN reports. request for a provisional detention, the first step in sending him to America to face charges for extorting money from the mother of missing teen Natalee Holloway.

    Joran van der Sloot, the convicted killer of a young Peruvian woman and the prime suspect replica Van Cleef ring in the disappearance of missing American teen Natalee Holloway, could soon be extradited to the United States. to extradite the Dutchman for extorting Holloway's mother. prisons have a reputation for being "very hard" on inmates, according to the Associated Press.

    On Jan. 13, Van der Sloot, 24, was sentenced to 28 years in prison for the murder of Stephany Flores.

    The Peruvian business student was found stabbed to death in van der Sloot's Lima hotel room on June 2, 2010. Police in Peru say Flores, 21, was killed on May 30, the five year anniversary of the disappearance of Natalee Holloway, an 18 year old from Mountain Van Cleef & Arpels ring copy Brook, Ala., who vanished while on a class trip to Aruba. She was last seen leaving an Oranjestad nightclub with van der Sloot, then a 17 year old Dutch honors student living in Aruba.

    Holloway's body has never been found, and van der Sloot has not been charged in her disappearance. on charges that he extorted $25,000 from the young woman's parents. Prosecutors said that in exchange for the money, he promised to reveal how Holloway died and the location of her body.

    Van der Sloot would probably face a five to 10 year sentence for the alleged extortion.

    The most recent developments were predicted months ago by Michael Griffith, senior partner at the International Legal Defense Counsel. In a previous interview with The Huffington Post, Griffith, whose most renowned case, involving an American incarcerated in a Turkish prison, was the basis for the film and book "Midnight Express." said he expected van der Sloot to be extradited. could get him in their grips for Holloway's alleged murder something that could earn him a life sentence. citizen. It kind of originated with the Leon Klinghoffer case," said Griffith.

    In 1985, Klinghoffer, 69, and his wife were celebrating their 36th wedding anniversary Van Cleef & Arpels rose gold ring fake on the cruise ship Achille Lauro. Palestinian terrorists hijacked the liner, and Klinghoffer was murdered and thrown overboard. military forces intercepted the plane and forced it to land in Italy, where the suspects were taken into custody.

    That principle, which has been used in limited cases, is being used more often today and could be applied to the Holloway case. Meanwhile, van der Sloot remains imprisoned at Piedras Gordas prison in Ancon.
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    Mobile Mini Inc MINI

    Mobile Mini, Inc., incorporated on July 21, 1993, is a provider of portable storage solutions. The Company, through its subsidiary, Evergreen Tank Solutions, Inc. (ETS), is a provider of specialty containment solutions in the United States. The Company's business consists of two product categories: portable storage solutions and specialty containment solutions. Portable storage solutions consist of its container and office product offerings. The Company offers a range of portable Van Cleef & Arpels gold ring replica storage products with features, such as locking systems, doors, electrical wiring and shelving. Its specialty containment products consist of liquid and solid containment units, pumps and filtration equipment. As of December 31, 2016, its network included 125 portable storage locations, 19 specialty containment locations and 14 combined locations.

    The Company's portable storage units provide storage across various industries, including retail and consumer services, construction, industrial, commercial and governmental. Its products are used for a range of storage applications, including retail and manufacturing, inventory, maintenance supplies, construction materials and equipment, documents and records, household goods and as portable offices. Its principal products are steel storage containers and steel ground level offices. As of December 31, 2016, its standard portable storage containers were available in lengths ranging from 5 to 48 feet, widths of either 8 feet or 10 feet and a range of customization options. Doors fake van cleef jewelry can be placed at the front, front and back, or the sides of containers. Other options include partitions and shelving.

    As of December 31, 2016, the Company offered steel ground level offices from 10 to 40 feet in length in various configurations, including office and storage combination units that provide a 10 or 15 foot office with the remaining area available for storage. products include canteen units and drying rooms for the construction industry. office/canteen units can also be stacked two or three high with stairs for access to the upper unit. These office units are equipped with electrical wiring, heating and air conditioning, phone jacks, carpet or tile, high security doors and windows with security bars or shutters. In addition, the Company offers ancillary products for rental and for sale to its customers, such as hoses, pipes, filters and spill containment. Its principal products and services include steel tanks, stainless steel tank trailers, roll off boxes, vacuum boxes, dewatering boxes, and pumps and filtration equipment. Its fleet of steel tanks offers flexible sizes and other options, such as gas buster steel tanks and open top steel tanks. Its applications include temporary storage of chemicals, water and other liquids, thorough mixing, agitation and circulation of stored liquids with other products, removal of gas from fluids circulated in the wellbore, such as mud used during drilling operations, and settling of solids in liquids prior to filtration or discharge. Its stainless steel tankers meet department of transportation specifications for use in the storage and transportation of chemical, caustics and other liquids. Stainless steel tanks are offered insulated or non insulated with level indication and vapor recovery capability.

    The Company's roll off boxes are utilized for a range of containment applications where it is necessary to maintain the homogeneity of the contents. The Company's roll off boxes provide leak proof storage and transportation of solid industrial byproducts. Vacuum roll off boxes are also offered to pair with a vacuum truck for containment, storage or transportation of pressurized contents. Its dewatering boxes are configured to provide for the draining of excess liquid from slurry or sludge. It offers a range of pumps and filtration equipment differentiated by size and power. This equipment is used for liquid circulation and filtration in municipal and industrial applications. It offers services, including transportation of containers for waste management between multiple locations or in plant; waste management oversight and service Van Cleef & Arpels wedding ring fake provision; system design, including assessment of pumping, filtration and temporary storage needs, and field services to install and connect customer containment equipment.

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    negative tumors with apocrine differentiation

    Androgen receptor in breast cancer: expression in estrogen receptor positive tumors and in estrogen receptor negative tumors with apocrine differentiation

    Leo A Niemeier1, David J Dabbs1, Sushil Beriwal2, Joan M Striebel1 and Rohit Bhargava1Received 13 April 2009; Revised 16 June 2009; Accepted 7 August 2009; Published online 6 November 2009.

    Top of pageAbstractAndrogens exert growth inhibitory effects on estrogen receptor and progesterone receptor negative breast cancer cell lines that show androgen receptor expression. These laboratory findings may be translated into inexpensive alternative therapies for hormone receptor negative invasive breast cancers. Our aim was to systematically evaluate androgen receptor expression by immunohistochemistry in invasive breast cancers. Androgen receptor (clone AR441, Dako) expression was analyzed on 189 well characterized consecutive invasive breast carcinomas represented with threefold redundancy on tissue microarrays. Androgen receptor expression was semi quantitated using a histochemical score like method and a score was considered positive. Of the 189 consecutive invasive breast cancers, 151 (80 were positive and 38 (20 were negative for androgen receptor. The majority (95 of estrogen receptor positive tumors were also androgen receptor positive. Six of eight estrogen receptor negative receptor positive cases showed apocrine differentiation. Androgen receptor expression in estrogen receptor positive cases was associated with smaller tumor size (P lower Nottingham grade (P and less frequent tumor cell necrosis (P Androgen receptor expression in estrogen receptor negative tumors was associated with lower Nottingham grade (P and apocrine differentiation (P In conclusion, most estrogen receptor positive breast tumors also express androgen receptor. Currently, invasive breast cancer is treated by multi modality therapy. Approximately 75 of breast cancers are positive for estrogen (ER) and progesterone (PR) receptor protein expression. This hormone receptor negative group includes triple negative tumors (negative for ER, PR and HER2) and a subset of tumors, which are positive for HER 2 (ERBB2). The HER2 positive tumors are now often treated with humanized monoclonal antibody to HER2 protein called trastuzumab in adjuvant, neo adjuvant and metastatic settings. However, triple negative breast cancers lack any specific targeted therapy at the current time.5 The search for more predictive bio markers is the primary aim and goal of breast cancer research.

    In an effort to identify additional predictive biomarkers, we studied androgen receptor (AR) expression in breast cancers. AR has biological and therapeutic utilization in prostate cancer, but its use in breast cancer treatment is limited because of the widespread and effective use of anti estrogen hormonal therapies and dearth of studies comprehensively analyzing AR expression in breast cancer.6 Recent literature has shown that Dehydroepiandrosterone and its sulfate have growth inhibitory effects on ER and PR negative breast cancer cell lines that show AR expression.7, 8, 9 The aim of our study was to examine the prevalence of AR positivity in the various subclasses of invasive breast cancer. Of particular interest was the percentage of AR expression in the hormone receptor negative group and if there were any recurring morphological features that were present in these tumors.

    Top of pageMaterials and methodsAR expression was evaluated on 189 consecutive invasive breast carcinomas represented on tissue microarrays with threefold redundancy. Four tissue microarrays were constructed using 0.6 cores on manual microarrayer MTA1 from Beecher Instruments, Sun Prairie, WI, USA. Four micrometer microarray sections were immunostained with AR antibody on the Dako automated stainer (Dako North America, Carpinteria, CA, USA). The protocol consisted of a pretreatment in Trilogy with EDTA (Cell Marque, Rocklin, CA, USA), in a steamer 30 at 95 and then cooled at room temperature for 30 Slides were then placed on the immunostainer and incubated with the AR antibody (clone AR441; dilution 1:50; Dako). The antigen complexes were detected by using mouse EnVision (Dako). AR expression was semi quantitatively scored using an H score like method described below. An immunohistochemical score was considered as a positive result.

    The tumor ER, PR, and HER2 status was available from pathology reports. Immunohistochemistry for ER and PR was performed using the 6F11 and 1A6 antibodies, respectively, and iVIEW detection on the BenchMark XT (Ventana, Tucson, AZ, USA) at the time of initial diagnosis. At our institution, ER and PR are scored using a semi quantitative H score like method which details the percentage of cells showing none, weak, moderate or strong staining.10, 11 The score is given as the sum of the percent staining multiplied by an ordinal value corresponding to the intensity level (0 1 2 and 3 With four intensity levels, the resulting score ranges from 0 (no staining Van Cleef & Arpels rose gold ring copy in the tumor) to 300 (diffuse strong staining of the tumor). An immunohistochemical score was considered a positive result for ER and PR. HER 2 protein was analyzed and scored using CB11 antibody and basic DAB detection on BenchMark XT (Ventana, Tucson, AZ, USA). HER 2 was considered as negative for immunohistochemical scores 0 and 1. HER 2 was considered as positive with either 3 immunoreactivity or unequivocal amplification by fluorescence in situ hybridization (PathVysion Vysis dual color FISH by Vysis, Downers Grove, IL, USA) in 2 cases. Cases with results by fluorescence in situ hybridization were considered as negative for HER2 in this study.

    Based on semiquantitative ER, PR and HER2 results, the tumors were divided in six groups corresponding to molecular classes as follows: Luminal A (LUMA; ER score of 200 or higher, any Van Cleef & Arpels gold ring copy PR and HER2 negative), Luminal B (LUMB; ER score of 11 or PR and HER2 negative), ERBB2 (ER and PR score of 10 or less and HER2 positive), Triple Negative (TN; ER and PR score of 10 or less and HER2 negative), Luminal A HER2 Hybrid (LAHH; ER score 200 or higher, any PR and HER2 positive), Luminal B HER2 Hybrid (LBHH; ER score of 11 or PR and HER2 positive).12 As the main distinction between luminal A and luminal B tumors on expression profiling was the quantitative expression levels of ER and ER related genes,13 we have used semi quantitative hormone receptor immunohistochemistry for this distinction. Therefore, pure luminal tumors (LUMA and LUMB) were classified as positive for hormone receptors and negative for HER2. We believe this distinction replica Van Cleef & Arpels ring is necessary as HER2 tumors are treated differently and need to be separated from pure luminal tumors, which should be further categorized as luminal A and luminal B tumors.

    The tumor AR expression was compared with known clinical factors including the above described molecular classes. Apocrine differentiation in the tumor cells was identified based on cytologic features such as abundant granular eosinophilic cytoplasm, cytoplasmic vacuolization round vesicular nuclei, often with prominent eosinophilic (occasionally basophilic) nucleoli.

    Statistical analysis was performed using SPSS software version 16.0. For comparison of means, independent sample t tests were performed. Univariate analysis was performed using and Fisher's exact tests to compare the differences in percentages between groups. An ANOVA test was performed to compare mean AR immunohistochemical scores and percentage cellular reactivity among different molecular classes. A P value was considered as significant.

    Top of pageResultsOf the total 189 cases, 151 (80 were positive and 38 (20 were negative for AR. The majority of ER tumors were also positive for AR (Table 1 and Figure 1). Only 8 of the 151 ER cases were negative for AR (5 Interestingly, five of these eight AR negative cases were also negative for PR. Details of semiquantitative AR immunohistochemical staining for both AR positive (H score and AR negative (H score 10 or less) cases is provided in Table 3. There was no significant difference with respect to mean AR H scores (P value, 0.806) or mean percentage of cell positivity (P value, 0.869) in AR tumors of different molecular classes. The cases classified as AR negative (H score 10 or less) were generally completely negative and showed an average reactivity in 1 of the tumor cells with H scores generally ranging from 0 (Table 3). The results that were significantly associated with AR negative tumors were of larger tumor size, higher Nottingham grade, and more frequent tumor cell necrosis. Although not statistically significant, a trend for frequent lymph node metastases was noted for AR negative tumors. As apocrine differentiation is commonly seen in ERBB2 tumors, 4 of the 5 AR ERBB2 tumors showed apocrine differentiation (Figure 2). Of the three AR TN tumors, two showed apocrine differentiation (Figure 3). Of all the 30 triple negative tumors, nine showed some degree of apocrine differentiation, but only two were positive for AR. The results that were significantly associated with AR negative tumors were higher Nottingham grade, and less frequent apocrine differentiation. Gonzalez et al22 showed AR reactivity in 74.8 of 111 breast carcinomas using the same antibody clone and dilution used in this study. In a series of 76 breast carcinomas, Isola23 identified AR expression in 79 cases. In a series of 100 snap frozen breast cancer tissues, Kuenen Boumeester identified AR expression in 76 cases.24 One large study of 488 cases from Poland has shown a lower rate (43.4 of AR expression in breast carcinoma, but this study also reported much lower rates of ER (39.3 and PR (24.6 expression.25 This study also used the same AR antibody clone and dilution as the current study and also used antigen retrieval. Whether this lower rate of steroid receptor expression was related to geographical distribution, tissue fixation or somewhat younger age of the patients (average age of 54 years) is unclear. Interestingly, criterion for positivity was not mentioned. Previous studies have also shown an association with ER expression23 and some reports indicated AR expression in ER negative tumors.24, 26

    In the last few years our understanding of breast carcinoma has significantly improved with discovery of breast cancer molecular classes using the gene set, that has prognostic significance.13, 27, 28 During the same time period, other gene expression based tests have also proliferated, but the core significance of ER, PR and HER2 as prognostic markers has not diminished. It appears that broad division of breast cancer into ER positive and ER negative groups has enormous biological and clinical significance. Therefore, ER, PR and HER2 have been used as immunohistochemical surrogate markers for molecular classes yielding comparable results.14, 29 We designed this study to analyze AR expression in breast carcinoma with respect to IHC defined molecular classes and also its relationship to other clinical factors.
    sdjisafhshfuk 4 hours ago
    Robert Fontaine Opens a New Joint

    A man teeters precariously on a faded yellow scaffold while plastering a wall. Beneath him another worker paints an office area that could easily substitute as a bar. Dust fills love ring replica cartier the air, and the screech of a hammer drill wails like a siren through the space.

    Nearby, 36 year old Robert Fontaine cartier love replica ring wedding band steps over a clot of tube cartons filled with silkscreen prints he's ready to ship to clients. There are also several of Paul Rousso's bath towel size acrylic sculptures of crumpled cash arranged on the floor as if they fell out of someone's pockets.

    The dancer trim Fontaine, who wears black wire rim glasses, jeans, and a nicely pressed dark gray shirt, nimbly navigates the busy, crowded room while taking stock of a growing collection of art.

    "Rousso's sculptures are some of my biggest sellers and are priced in the $8,500 range. Troy Abbot, who is local, is also hot now and can't keep up with the demand for his work," Fontaine says while studying the blueprints for his new space. He mentions he's been selling an average of "five to ten works a week" since opening a gallery in Wynwood in February 2011.

    Fontaine says he made a six figure salary last year. Not bad for a guy who just a couple of years ago was traveling with Marilyn Manson trying to sell the musician's artwork while he was on tour. "Basically I organized shows for him in Zurich, Moscow, S Paulo, Athens, and Cologne and sold his work while trying to get my foot in the art world."

    During this month's Wynwood Art Walk, he will inaugurate the new Robert Fontaine Gallery (2349 NW Second Ave., Miami) with "Collective Memory," a solo show by London based artist Nick Gentry, who creates large cartier gold replica ring scale portraits using floppy discs attached to Masonite board that he then paints. In a back room of the gallery, Fontaine will also exhibit works by iconic museum artists.

    "The new space is twice the size of the former one," Fontaine says. "It's across from Panther Coffee and has 20 foot ceilings and is over 2,000 square feet in size, so I will be showing works by Andy Warhol, Robert Rauschenberg, Jasper Johns, and Tom Wesselmann, among others from my collection. this Saturday with a plethora of new shows, ranging from a Parisian shutterbug's photos of famous celebrities, to an exhibit riffing on El Generalissimo Franco and fascist era iconography, to the contents of a manmade underwater reef dredged up from the coast and plopped inside a Wynwood space.

    Florida Grand Opera will also jump onto the art walk bandwagon by hosting a preview of Rom et Juliette at the always buzzing Dorsch Gallery.

    Here are our picks for what not to miss during this weekend's rollicking arts bash. There will be something for everyone to enjoy.

    At the Lelia Mordoch Gallery (2300 N. Miami Ave., Miami), "1010 Portraits" features Paris lensman Didier Gicquel's large black and white gelatin silver prints of film, art, music, and literary luminaries captured while visiting the City of Lights.

    Since 1979, the photographer has used a battered old camera with a Leica lens to take pictures of personalities such as James Ellroy, Patti Smith, Francis Ford Coppola, Henri Cartier Bresson, Larry Clark, David Lynch, Johnny Depp, and a host of other celebrities with a passion for France. Gicquel's shots are soulful and speak to the universal cult of celebrity with a natural, unposed air.

    Primary Projects in the Design District (4141 NE Second Ave., Ste. 104, Miami) delivers the heroic and the ridiculous with University of Arizona professor and conceptual artist Lawrence Gipe's over the top foray into fascism, "In the Valle de los Caidos."

    Gipe's solo boasts epically scaled mixed media paintings on raw canvas, a video installation, and a collection of small works delving into the enormous cathedral that Gen. Francisco Franco had built as a tomb for himself in the Sierra de Guadarrama near Madrid, using prisoners of war as slave labor.

    Gipe has sourced imagery for his exhibit from historical photos, propaganda films, present day blogs from both the right and left of the divisive controversy surrounding the site, and even a Franco era thriller that used the church grounds as a set.

    At the Charest Weinberg Gallery (250 NW 23rd St., Miami), German artist Hannes Bend presents "Eclipse," a multimedia re creation of a natural disaster wrought by man. For his arresting exhibit, Bend has filled the gallery space with hundreds of rotting tires dredged from the Osborne Reef, expanded in 1972 when the Broward Artificial Reef Company began dumping old automobile tires off the coast in an attempt to attract more marine life. With more than 2 million rubber tires sitting underwater today, Osborne has been declared an ecological catastrophe, and Bend's project, which also features photography and video, draws attention to the 30 acre site.

    The Dorsch Gallery (151 NW 24th St., Miami) is staging a pair of exhibits intended to appeal to nostalgia for youthful playgrounds and our inner math nerd. The first, "For Old Times' Sake," is a solo by local sculptor Ralph Provisero. It features a monumental kinetic sculpture titled Spring Rider, for which the artist retooled an old school fiberglass child's car and tricked it out with a motor to make the toy wheels dance. The second show, "Let's Begin With a Line," is a group offering that comprises a selection of works riffing on the aesthetic pleasures of symmetry and the linear.

    "Because of the nature of Art Walk, with its mixture of new and veteran art viewers, it is possible to surprise, convert, and enchant," gallery director Tyler Emerson Dorsch says. "An operatic performance of Rom et Juliette is very different from the exhibitions and punk and sound performances we have at the gallery, and so this occasion is an intervention of sorts or to use an art term a happening to break habits of cartier ring replica rose gold thought. In the shock that ensues, we'll have some fun."

    "People are actually visiting the area in droves and not just on Second Saturdays anymore," mentions Fontaine, who bristles at the notion he's just another trust fund kid with his name plastered across a Wynwood gallery fa me now, the risk is greater, but it makes you work harder."
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    Maple Leafs have the right to believe they can beat Capitals

    WASHINGTON This is a series. More than even that. This is a coming out party for a franchise that has been down far too long.

    This is remarkable and stunning for the young Toronto Maple Leafs. This is a beginning and a statement all at the same time. This is the opportunity of a lifetime for a team just learning to do this.

    It isn just that the Leafs are tied after two games with the Washington Capitals. It how they are tied. It who they have had to rely on. It everything.

    Kasperi Kapanen, who wasn even a Leaf until a few weeks ago, when injuries forced his callup from the American Hockey League, scored Toronto second goal and the double overtime winner at 11:53 of the fifth period on a magnificent semi blind backhand pass from his fourth line centre, Brian Boyle.

    The Leafs beat the Capitals 4 3 to tie the best of seven series at 1 1 and now, all bets are off. The Leafs have to be believing in themselves. They have to be flying home with an understanding that not only is this series tied, but it could have been a 2 0 lead for Toronto. To win in the playoffs, you have to seize moments and opportunities and make plays in tight spaces. The Leafs did all of that Saturday night.

    And now it a best of five. With expectations closing in on the Capitals, who forever come up short in the post season, no matter what the circumstance.

    Really, it is hard to know where to begin with these young Maple Leafs. From their undermanned defence to terrific goaltending. To the commanding work of Morgan Rielly and Jake Gardiner. To the strength on the puck of Auston Matthews, the work of Zach Hyman, the flash of William Nylander and Mitch Marner, the faceoffs won by Tyler Bozak.

    And a game won by a rookie, set up by a veteran, won by a fourth line.

    Here were the Maple Leafs, barely in the playoffs, against the No. 1 team in the National Hockey League, in overtime in Game 1 at the Verizon Center, back in overtime again in Game 2, into a second overtime period late Saturday night.

    And almost all of this without Roman Polak, who went down, probably for what left of the season, after a first period collision with veteran Brooks Orpik on the Washington defence. The Leafs were already without stalwart rookie, Nikita Zaitsev. Then without the hard playing Polak.

    And down to five D. And not the ideal five D.

    Rielly played what coach Mike Babcock called his best game of the season in Game 1. In Game 2, he was better. Gardiner, victimized in the third period when Nicklas Backstrom scored the game tying goal, fake Van Cleef & Arpels ring made a marvellous play on the first goal of the night by James van Riemsdyk. That normally what you get from Gardiner, a little great, a little good, some shake your head how did that happen stuff but again, like his compatriots against the Capitals in Game 2, he was mostly terrific.

    Heading into the second intermission, Rielly had played more than 35 minutes, Gardiner was over 34 minutes, the veteran Hunwick over 30 minutes the most any of them had ever played in an NHL game.

    By midway through the second overtime period, Rielly and Gardiner had topped the 40 minute mark of ice time, Hunwick above 35 minutes.

    Basically, Babcock settled on four defencemen, keeping Connor Carrick on the bench for much of the second half of the game, relying on little used Martin Marincin for more than 26 minutes, which is miraculous on its own. He did go back to Carrick in the second overtime period.

    And that what this team is about. It not about one guy. It about just a goalie. It not one pair. It not just youth. It not just coaching. It not just about speed and remarkable skill.

    It a team that might not be aware of exactly where they are and what they accomplishing here, but with the three time champion Chicago Blackhawks down 2 0, having yet to score a goal in the playoffs. imitation Van Cleef ring The Leafs have scored more, won more than Chicago.

    At times, Alex Ovechkin can look unstoppable, but the Leafs have mostly handled him. He scored a power play goal in the second period, from his usual spot, but he also had an opportunity to win the game with 1:38 left in regulation time, the puck on his stick, a shot that seemed to beat Andersen, but somehow got a piece of the goaltender and the puck slid wide.

    The puck went to Kapanen at the side of the crease and he wasted no time in scoring. The kid is on the rise. This team is on the rise.

    WASHINGTON This is a series. More than even that. This is a coming out party for a franchise that has been down far too long.

    This is remarkable and stunning for the young Toronto Maple Leafs. This is a beginning and a statement all at the same time. This is the opportunity of a lifetime for a team just learning to do this.

    It isn just that the Leafs are tied after two games with the Washington Capitals. It how they are tied. Van Cleef & Arpels gold ring imitation It who they have had to rely on. It everything.

    Kasperi Kapanen, who wasn even a Leaf until a few weeks ago, when injuries forced his callup from the American Hockey League, scored Toronto second goal and the double overtime winner at 11:53 of the fifth period on a magnificent semi blind backhand pass from his fourth line centre, Brian Boyle.

    The Leafs beat the Capitals 4 3 to tie the best of seven series at 1 1 and now, all bets are off. The Leafs have to be believing in themselves. They have to be fly
    sdjisafhshfuk 4 hours ago
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